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In vivo scientific studies show anatomically selective neurochemical effects of modafinil on monoaminergic techniques (de Saint Hilaire et al 2001; Ferraro et al 2002), and, notably, whilst modafinil increases TMN fos expression (Scammell et al 2000) and HAergic tone it is not able to exert this effect when administered directly in to the TMN (Ishi

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